306 Exploring the relationship between acne and mental health

Acne vulgaris is a highly heritable and common skin disorder. lesions primarily impact facial severely inflamed may leave permanent scars that have been associated with long-term psychosocial consequences. Individuals severe acne reported to elevated rates of depression, anxiety, suicidal ideation other mental health disorders. Nonetheless, the shared biology between these disorders direction causality remains unclear. We used summary statistics from largest available genome-wide association studies date, examine genetic overlap seven Next, we applied Generalised Summary-data-based Mendelian Randomisation test for evidence possible causal relationships each Increased risk was significantly genetically correlated increased schizophrenia bipolar disorder – correlation occurring (rg = 0.18; P=6.7e-05) an score predicted history anxiety (P<0.001). also observed relationship depression (OR=1.04 [95% CI 1.02-1.07]). Here, show pathways jointly influence several disorders, suggesting co-morbidity be mediated, provide causation. Future work will consist further interrogation results, particularly through exploration regional genomic underlying pathway analysis. These results novel insight into mechanisms which improve our ability diagnose, prevent or manage such conditions.